Background

GenoTyping Reports

GENETIC REPORTS FOCUSED ON THE CARRIER STATUS OF SNPS RELATED TO GENERAL WELLNESS

 

These reports are best to look at the GenoTypes of specific SNPs or variants in familiar genes like MTHFR, COMT, APOE or other genes commonly seen in general wellness reports.

 

If you thought GeneSavvy would create just another “standard SNP report” that is just like everyone else, you’d be wrong! Scroll down to see why our GenoTyping reports are better.

 

Get General Wellness Report

What is a “SNP”?
Pronounced: (Snip)

Single Nucleotide Polymorphism

  • S

    SINGLE – [siNGɡəl]: Only one; not one of several.   We commonly visualize DNA as a twisted double helix and If we un-twist that double helix, it starts to look like a ladder with a bunch of rungs or steps on it. Each one of those rungs or connectors in the ladder represents a single location in our DNA that can carry a change. The changes at each single location can generally called variants, mutations, or SNPs.

  • N

    NUCLEOTIDE – [n(y)o͞oklēəˌtīd]: Nucleotides form the basic structural unit of nucleic acids such as DNA.   Using the common “double helix” visual example of DNA, when we un-twist that helix, it looks a lot like a ladder with many rungs or steps on it. Each rung or step on that ladder represents a single location where 2 nucleotides have paired together. These paired nucleotides are generally called “base-pairs” since they are paired together using our base nucleic acids commonly known as A,G,C, and T.

  • P

    POLYMORPHISM – [pälēˈmôrfizəm]: The presence of genetic variation within a population, upon which natural selection can operate.  In 2003 the Human Genome Project completed what we consider “the reference human genome”. When we do genetic testing, we compare your results to the reference genome and report any variations or changes carried by that person. Over time, we have identified single nucleotide locations that are known to have common base pair changes within different populations. These common nucleotide change locations are generally referred to as “SNP”s or single nucleotide polymorphisms, and identifying a person’s (base pair)carrier status at these SNP locations allows us to try and predict how they will respond to their environment based on historical data of the populations with shared base pair carrier status.

Variant Exploration Files VS Report Files

  • NADH dehydrogenase
  • CoQ - Cytochrome C Reductase/Cytochrome B
  • Cytochrome C Oxidase
  • ATP Synthase
  • Humanin
  • Ribosomal RNA (rRNA)
  • Transfer RNA (tRNA)
Mitochondrial Gene Functions

Variant Exploration Files

Our Variant Exploration Files are organized spreadsheets created from the VCF files provided by your genetic sequencing lab. These files will contain information on all of the variants listed in the VCF file you provide (usually ~30,000 variants). We annotate all these variants from data sources that provide useful information related to its function. We also apply our own scoring algorithm which we use to help identify variants with the highest potential impact your health or other traits.

 

View Example Exploration File!

Health Report Files

Our Health Report Files are PDF files that are focused on a subset of genes related to a health topic. These files are generally much easier to follow and will contain actionable suggestions based on the findings within. There are 2 main types of Health Reports that we offer.. Genotyping Reports (reports focused genes known to impact health) and Phenotyping Reports (reports focused on symptoms where the causative genes might not be known yet).

Age 0-20 (10 ng/mg Protein)
Age 21-40 (5 ng/mg Protein)
Age 41-60 (2.5 ng/mg Protein)
Age 61-80 (1.25 ng/mg Protein)
Age 80+ (0.5 ng/mg Protein)

Annotation Databases Used

We use a large amount of 3rd party databases along with our own databases to create useful data related to your variants! Here are some of the data sources you will find in our reports:

  • GeneFTX
  • RefSeq
  • ENSEMBL
  • dbSNP
  • ClinVar
  • OMIM
  • GWAS
  • MitoMap
  • SIFT
  • PolyPhen2
  • LRT
  • MutationTaster
  • FATHMM
  • InterVar
  • CADD
  • GERP++
  • ExAC
  • gnomAD
  • 1000 Genome Project
  • NCBI
  • Plus More!

The Science

Results You Can Trust

GeneSavvy processes your genetic information in our state-of-the-art genetic lab using advanced management protocols during the processing and delivery of your results to ensure the best and most reliable results we can deliver.

At GeneSavvy we have developed several proprietary tools to be incorporated in this process including our TriarKK™ bioinformatic pipeline.

Treatment Modalities Combined

At GeneSavvy our advisors, panel curators, and treatment option experts have come together from all different modalities of the health industry to provide well rounded treatment options without bias towards one or the other, its all about providing the best action for you. Specialties include:

  • Medical Doctors
  • Naturopathic Doctors
  • Doctors of Osteopathic Medicine
  • Chiropractors
  • Genetic Counselors
  • Nutritionists and Other Functional Medicine Professionals.

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