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In: Genetics

Genetic Influence on Thyroid Stability Many people suffer the effects of thyroid disease which include hypothyroidism, hyperthyroidism, Grave’s disease, Hashimoto’s thyroiditis (autoimmune thyroiditis), generalized thyroid inflammation and thyroid cancer. Unrelated human subjects share 99.9% of their genome. It has been estimated that 90% of the remaining variation is accounted for by approximately 10 million common single nucleotide polymorphisms (SNPs), single base changes spread throughout the genome. These are very useful in studying gene-phenotype associations as they occur commonly in the general population, and may either cause changes in gene function themselves, or more frequently are markers of nearby elements that...
Gene Patterns of Chronic Migraine Headaches   Migraines Are Heritable Gene patterns in migraine headaches demonstrate strong association with sensitivity and susceptibility in families. Migraine headaches are known to cluster in families and have long been considered to be an inherited disorder. Migraine, with aura or without aura, has a substantial risk of familial occurrence, and genetic epidemiologic studies suggest that migraine without aura and migraine with aura have distinct and unique heritability. Twin studies reveal that approximately one half of the variation in migraine is attributable to additive genes, while the remainder is caused by unshared rather than shared...
Nutritional and Metabolic Gene Status With Autism Versus Neurotypical Children and the Association with Autism Severity   Introduction Current research demonstrated a strong relationship between the genes that control nutrition and metabolic function that manifest as early childhood developmental disorders. Studies reveal low levels of biotin, plasma glutathione, RBC SAMe, plasma uridine, plasma ATP, RBC NADH, RBC NADPH, CoQ10, plasma sulfate, plasma tryptophan, dopamine, glutathione, high level of oxidative stress markers and plasma glutamate. https://doi.org/10.1186/1743-7075-8-34   Genes Implicated There are many implicated genes in Autism and Neurotypical children that demonstrate possible pathway disturbances that involve key functional proteins and enzymes...
Expressed Phenotype and Epigenetic Reprogramming Phenotype An individual's phenotype consists of the traits we can observe. These can include features of appearance, behavior, metabolism, immunity or anything else we can detect. Collectively, genes make up the observable phenotype. The phenotype expression can be influenced by a variety of factors and generational implications. [1] Phenotype Expression The phenotype is also known as the clinical expression of a specific disease. For instance, in cases of neurodevelopment disorders, Autism is an expression of the phenotype. In inherited familial high cholesterol, the expressions of the genes that control this metabolism are the phenotypes. Phenotypic abnormalities can...
August 16, 2017

GeneSavvy Press Release

For Immediate Release: 7/26/17   GeneSavvy Announces Launch in Emerging Wellness as a Service (WaaS) Industry   Former Courtagen Employees to Team Up with GeneSavvy     GeneSavvy, a division of HealthSavvy, Inc. based in Kenmore, WA announces their launch into the emerging Wellness as a Service industry with genome-centric biotechnology built to promote vibrant health through their proprietary decision management software. GeneSavvy Co-Founder and CEO Kris Fobes has been developing GeneSavvy’s intelligent clinical decision platform since 2012 with the launch of subsidiary company, HealthCoach7. HealthCoach7 is a genetic health company focused on developing and providing diagnostics and treatments for...
Mitochondria are the energy producers of human cells. The energy currency for the work that is required to power up metabolism by producing the energy-rich molecule adenosine triphosphate (ATP). The ATP is produced in the mitochondria using energy stored in the food that is consumed. These ATP's are essential in keeping every step of metabolism in equilibrium which in turn effects every system of the human body including immunity, detoxification, hormones, brain neurotransmitters, etc. Genetic testing to determine metabolic efficiency in chronic health concerns is essential. Also essential in conditions like OCD, ADHD, ASD (Autism), Fatigue, Immune Related Fatigue, Chronic...
There are hundreds of mitochondria within human cells and it is crucial to protect the mitochondria from age-related stress and oxidative burden in order to prevent functional disease and aging risk. These mitochondria are power generators that are responsible for the cell grid. If they are compromised the functional performance survival of the cell is jeopardized complete loss can result. Each mitochondria carries its own small circular DNA genome, called mtDNA, the products of which are required for energy production. Because mtDNA has limited repair abilities, normal and mutant versions of mtDNA are often found in the same cell, a condition...
August 8, 2017

Autism and Connectivity

New gene discoveries that code for neuronal connectivity are beginning to give new hope in targeting therapy to address the problems associated with connectivity. The autism spectrum brain exhibits connectivity disturbances that alters communication between neuronal regions. Neuronal mitochondrial depletion is among the causative factors that create impaired connectivity and synaptic control. There are many genes implicated in this phenomenon. Genes Studied In ASD http://www.genecards.org/Search/Keyword… Research Article Links https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691066/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420970/
Autism symptoms can be aggravated by inflammatory activity, chronic sensitivity and neurotransmitter trafficking. There are a variety of combination of therapeutically effective agents in personalized treatment. Some Guidelines 1. Disodium cromoglycate (Gastrocrom) ‘Mast cell stabilizer’ 100 – 400 mg/day dissolved in water 2. Cyproheptadine (Periactin) Serotonin and histamine-1receptor antagonist 1 – 4 mg/day 3. Ketotifen (Zaditen) Histamine-1receptor antagonist, anti-eosinophil 1 – 4 mg/day 4. Rupatadine (Rupafin) Histamine-1 receptor and platelet activating factor antagonist; mast cell inhibitor, anti-eosinophil 20 mg/day 5. NeuroProtek Contains flavonoids and a proteoglycan Two capsules/20 kg body weight/day and Nrf2 as additional item 6. Black Seed Oil...
Personalized genetics are indeed, personal, powerful, revealing, and relating to an individual's wellness and longevity. Next generation sequencing and whole exome technology has allowed for the complete capture of the entire human genome. We have worked with countless numbers of adults and children with complex diseases including autism, neurological development disorders, immunological disorders, metabolic disorders and rare disease with successful cases all over the world.  Genetic testing is the foundation of discovering more exact diagnostic testing and treatable actions. Tens of thousands of dollars can be saved by discovering the genes and associated pathways before running costly lab testing. Treatment...