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December 2017

Genetic Influence on Thyroid Stability Many people suffer the effects of thyroid disease which include hypothyroidism, hyperthyroidism, Grave’s disease, Hashimoto’s thyroiditis (autoimmune thyroiditis), generalized thyroid inflammation and thyroid cancer. Unrelated human subjects share 99.9% of their genome. It has been estimated that 90% of the remaining variation is accounted for by approximately 10 million common single nucleotide polymorphisms (SNPs), single base changes spread throughout the genome. These are very useful in studying gene-phenotype associations as they occur commonly in the general population, and may either cause changes in gene function themselves, or more frequently are markers of nearby elements that...
Gene Patterns of Chronic Migraine Headaches   Migraines Are Heritable Gene patterns in migraine headaches demonstrate strong association with sensitivity and susceptibility in families. Migraine headaches are known to cluster in families and have long been considered to be an inherited disorder. Migraine, with aura or without aura, has a substantial risk of familial occurrence, and genetic epidemiologic studies suggest that migraine without aura and migraine with aura have distinct and unique heritability. Twin studies reveal that approximately one half of the variation in migraine is attributable to additive genes, while the remainder is caused by unshared rather than shared...